AI Use Cases

Use case	Agency	Stage	High-impact	Topic area	AI classification	Sourcing
CDER Regulatory Science Research (RSR) Projects AI for Process Control in Advanced Manufacturing R0837 · HHS/FDA/CDER	HHS	Deployed	Presumed high-impact, determined not	Science	Classical / predictive ML	Developed in-house
Developing an Objective and Quantitative Endpoint for Atopic Dermatitis in Pediatric and Adult Populations R0839 · HHS/FDA/CDER	HHS	Deployed	Presumed high-impact, determined not	Health and Medical	Classical / predictive ML	Purchased from vendor
Internal Referral Module (IRM) R0919 · HHS/NIH	HHS	Deployed	Presumed high-impact, determined not	Administrative Functions	Classical / predictive ML	Contract and in-house
NICHD RPAB AI/ML Application Referral System R0930 · HHS/NIH	HHS	Deployed	Presumed high-impact, determined not	Administrative Functions	Classical / predictive ML	Developed in-house
NLP Automated Referral R0931 · HHS/NIH	HHS	Deployed	Presumed high-impact, determined not	Administrative Functions	Classical / predictive ML	Developed in-house
NICHD RPAB AI/ML NICHD Relevance Model R0901 · HHS/NIH	HHS	Pilot	Presumed high-impact, determined not	Administrative Functions	Classical / predictive ML	Developed in-house
Enhanced Direct Enrollment Outlier Detection R0741 · HHS/CMS/CCIIO	HHS	Pre-deployment	Presumed high-impact, determined not	Information Technology	Classical / predictive ML	Not reported
Agent/Broker Fraud Analysis (ABCQI) R0745 · HHS/CMS/CCIIO	HHS	Pre-deployment	Presumed high-impact, determined not	Information Technology	Classical / predictive ML	Not reported